First Author:   Thi Hong Hanh Pham CARE - EMR, University of Rouen, France hanh.phamhong@gmail.com   University of Rouen, 3, avenue Pasteur Rouen, Cedex 1, F-76186, France   +33 2 32 76 96 56(Phone) +33 2 32 76 96 56(Fax)